The scientists found a way to make blood from adult human skin.
The breakthrough finding could mean that in the future, people will need blood for surgery, cancer treatment or treatment of other diseases associated with blood such as anemia, can get the blood resulting from a piece of their own skin for transfusions. Clinical trials could begin in 2012 possible.
Mick Bhatia who is the scientific director of McMaster's Stem Cell and Cancer Research Institute in the Michael G. DeGroote School of Medicine and his team of researchers also showed that the conversion is direct. Making blood from skin does not require intermediate steps that transform stem cells or skin stem cells become pluripotent stem cells that can make many types of other human cells, then turning them into blood stem cells.
The breakthrough finding could mean that in the future, people will need blood for surgery, cancer treatment or treatment of other diseases associated with blood such as anemia, can get the blood resulting from a piece of their own skin for transfusions. Clinical trials could begin in 2012 possible.
Mick Bhatia who is the scientific director of McMaster's Stem Cell and Cancer Research Institute in the Michael G. DeGroote School of Medicine and his team of researchers also showed that the conversion is direct. Making blood from skin does not require intermediate steps that transform stem cells or skin stem cells become pluripotent stem cells that can make many types of other human cells, then turning them into blood stem cells.
"We show that it is successfully carried out using human skin. We know how it works and believe we can even optimize the process," said Bhatia. "Now we continue to work on developing other types of human cell types from skin because we already have convincing evidence." Similarly, as quoted from Physorg (07.11.10).
The discovery was replicated several times over two years using human skin from both young and old to prove that it can be performed on people of all ages.
"The original findings are the first findings to show that human skin cells can be directly converted into blood cells through the process of programming without pluripten stage. Producing blood from the patient's own skin has the potential to eliminate compatibility issues and lack of donor bone marrow transplantation human leukocyte antigen (HLA), "said Christine Williams, PhD, Director of Research at the Canadian Cancer Society Research Institute.
The discovery was replicated several times over two years using human skin from both young and old to prove that it can be performed on people of all ages.
"The original findings are the first findings to show that human skin cells can be directly converted into blood cells through the process of programming without pluripten stage. Producing blood from the patient's own skin has the potential to eliminate compatibility issues and lack of donor bone marrow transplantation human leukocyte antigen (HLA), "said Christine Williams, PhD, Director of Research at the Canadian Cancer Society Research Institute.
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